1 H-[ 13 C]-NMR Investigations of Glutamatergic and GABAergic Metabolism in Aluminium Chloride Model of Alzheimer's Disease

Long term exposure of aluminium in rodents has been shown to form amyloid oligomer, similar to Alzheimers disease (AD) pathology. The present study evaluates the effects of chronic aluminium exposure on the cortical metabolism associated with glutamatergic and GABAergic neurons. The metabolism was studied using ¹ H-[ ¹³ C]-NMR spectroscopy in conjunction with infusion of [1,6- ¹³ C ₂ ]glucose in mice treated with aluminium (i.p.). The chronic exposure of aluminium reduced TCA cycle and neurotransmitter cycle fluxes of the excitatory and inhibitory neurons.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.