Abstract #2976
1 H-[ 13 C]-NMR Investigations of Glutamatergic and GABAergic Metabolism in Aluminium Chloride Model of Alzheimer's Disease
Anant Bahadur Patel 1 , Kamal Saba 1 , Vivek Tiwari 1 , and Pandichelvam Veeraiah 1
1
NMR Microimaging and Spectroscopy, CSIR-Centre
for Cellular and Molecular Biology, Hyderabad, Andhra
Pradesh, India
Long term exposure of aluminium in rodents has been
shown to form amyloid oligomer, similar to Alzheimers
disease (AD) pathology. The present study evaluates the
effects of chronic aluminium exposure on the cortical
metabolism associated with glutamatergic and GABAergic
neurons. The metabolism was studied using
1
H-[
13
C]-NMR
spectroscopy in conjunction with infusion of [1,6-
13
C
2
]glucose
in mice treated with aluminium (i.p.). The chronic
exposure of aluminium reduced TCA cycle and
neurotransmitter cycle fluxes of the excitatory and
inhibitory neurons.
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