Abstract #2993
Robust BOLD activation outside visual and motor cortex during a simple visual and motor task detected by whole-brain T2-prepared spin-echo (SE) BOLD fMRI at 7T
Jun Hua 1,2 , James J Pekar 1,2 , Peter C.M. van Zijl 1,2 , Qin Qin 1,2 , Craig K Jones 1,2 , and Jeffrey M Yau 3
1
The Russell H. Morgan Department of
Radiology and Radiological Science, Division of MR
Research, The Johns Hopkins University School of
Medicine, Baltimore, MD, United States,
2
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, MD, United States,
3
Department
of Neurology, The Johns Hopkins University School of
Medicine, Baltimore, MD, United States
Localized BOLD activations in visual/motor cortex are
typically observed during visual/motor tasks. Recent
studies show that BOLD activities can be detected in
many other regions during such tasks. Here, we performed
whole-brain fMRI experiments with simultaneous
flashing-checkerboard and finger-tapping using GRE-EPI,
SE-EPI and T2-prepared SE-BOLD fMRI. Robust activations
outside visual/motor cortex can be detected by
T2prep-BOLD, but not GRE/SE-EPI. CNR in these regions
was greater in T2prep-BOLD, mainly due to much reduced
dropout and distortion compared to EPI. This implies
that important information might be missed in these
regions with GRE/SE-EPI, especially for cognitive fMRI
studies with sophisticated tasks.
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