Abstract #2994
Longitudinal Measurement of CBF and CBV Using Arterial Spin Labeling and Steady State Contrast Enhancement fMRI
Iris Asllani 1,2 , Shazia Dharssi 3 , Richard P Sloan 3 , and Scott A Small 3
1
Biomedical Engineering, Rochester Institute
of Technology, Rochester, NY, United States,
2
Rochester
Center for Brain Imaging, University of Rochester, NY,
United States,
3
Columbia
University, NY, United States
To study the effects of normal aging and disease
progression on the brain function, we need to develop
fMRI methods that provide both quantifiable and reliable
measures of metabolism over the time-scales involved in
these processes. To this end, we have developed an fMRI
method that combines ASL perfusion fMRI with steady
state contrast enhanced (SSCE) fMRI to image CBF and CBV,
concomitantly. Here we report on the test-retest
reliability of this method by comparing CBF and CBV
images acquired on older subjects at two time-points, 90
days apart.
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