Complex interactions of physiological noise and acceleration on tSNR in 3D EPI

3D EPI provides a number of advantages over 2D multi-slice acquisition for high-resolution fMRI. However, the temporal signal characteristics of 3D sampling have not been fully characterized, particularly with respect to the interaction of physiological noise and acceleration. In this work we looked at the effect of varying slice acceleration factors on temporal SNR at different resolutions for in vivo and phantom acquisitions. We found a significantly different behavior of the in vivo tSNR compared to predictions based on thermal noise considerations alone. We present an investigation into potential sources of these effects.

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