Abstract #3021
Parametric event related fMRI to investigate non-linear BOLD effects in motor task
Adnan Alahmadi 1,2 , Rebecca Samson 1 , David Gasston 3 , Matteo Pardini 1,4 , Karl Friston 5 , Ahmed Toosy 1,6 , and Claudia A.M. Wheeler-Kingshott 1
1
NMR Research Unit, Department of
Neuroinflammation, Queen Square MS Centre, UCL Institute
of Neurology, London, United Kingdom,
2
Department
of Diagnostic Radiology, Faculty of Applied Medical
Science, KAU, Jeddah, Saudi Arabia,
3
Department
of Neuroimaging, Institute of Psychiatry, King's College
London, London, United Kingdom,
4
Department of
Neurosciences, Ophthalmology and Genetics, University of
Genoa, Genoa, Italy,
5
Wellcome
Trust Centre for Neuroimaging, UCL Institute of
Neurology, London, United Kingdom,
6
NMR
Research Unit, Department of Brain Repair and
Rehabilitation, Queen Square MS Centre, UCL, London,
United Kingdom
We have investigated non-linear responses in BOLD using
a parametric fMRI power grip motor experiment with five
target grip force levels in healthy volunteers. We have
demonstrated the ability to detect a complex BOLD
response to grip force modulation, affecting different
brain regions. The study showed linear and non-linear
BOLD responses to varying grip forces in the primary
motor cortex and non-linear responses (up to the 4th
order) in other motor and non-motor areas. We concluded
that BOLD signal and force have a complicated
relationship that is far from a simple correlation and
further physiological confirmations are warranted.
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