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Abstract #3022

Age-Related Change of Brain Activation During Virtual Performance of Combined Operation Task is Most Detected at Task Switching Timing An ER-fMRI Study

Toshiharu Nakai 1 , Ayuko Tanaka 1 , Mitsunobu Kunimi 1 , Sachiko Kiyama 1 , and Yoshiaki Shiraishi 2

1 NeuroImaging & Informatics, NCGG, Ohbu, Aichi, Japan, 2 Computer Science and Engineering, NITECH, Nagoya, Aichi, Japan

An event-related fMRI using virtual performance of a hand manipulation test for elderly was designed to investigate the neural basis of potential cognitive decline. Precise timing of three visuo-motor operations to transfer a target object to the goal was recorded by using turnkeys to define the time series of the events. It was demonstrated that activation of dorsal visual pathway was augmented in the elderly group when the visuo-motor performance was switched, suggesting thatswitching cost may be a more sensitive index as age related change than the other cognitive processing used for three steps of visuo-motor task.

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