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Abstract #3026

Auditory Midbrain Encoding of Ultrahigh Frequency Sound

Patrick P. Gao 1,2 , Jevin W. Zhang 1,2 , Iris Y. Zhou 1,2 , Joe S. Cheng 1,2 , Dan H. Sanes 3 , and Ed X. Wu 1,2

1 Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, HKSAR, China, 2 Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, HKSAR, China, 3 Department of Biology, New York University, New York, NY, United States

Ultrahigh frequencies (UHFs) are important for social communication of many species (e.g. higher than 40/60 kHz for rats/mice, respectively). While lower frequencies are known to be represented as tonotopy in the auditory system, it remains largely unclear how the UHFs are encoded and processed. In the auditory pathway, the inferior colliculus (IC) is a midbrain nucleus targeted by both ascending and descending auditory projections, thus a key station for auditory information processing. In this study, non-invasive BOLD fMRI was applied to investigate the underlying mechanisms of UHF encoding in the IC.

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