Abstract #3027
Functional Magnetic Resonance Imaging of the Rat Central Auditory System Following Chronic Intermittent Hypoxia
Condon Lau 1 , Jevin W Zhang 2,3 , Wing-Ho Yung 4 , and Ed X Wu 2,3
1
Division of Biomedical Engineering, HKUST,
Kowloon, Hong Kong,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Hong Kong, Hong Kong,
3
Laboratory
of Biomedical Imaging and Signal Processing, The
University of Hong Kong, Hong Kong, Hong Kong,
4
School
of Biomedical Sciences, The Chinese University of Hong
Kong, New Territories, Hong Kong
The brain depends on an adequate oxygen supply and
hypoxia occurs when the supply is inadequate. Chronic
hypoxia is a significant feature of multiple health
conditions and occupations that have been associated
with hearing disorders. We employed BOLD fMRI to
investigate the effects of chronic intermittent hypoxia
on central auditory physiology in an animal hypoxia
model. Larger fMRI responses are observed in both
auditory cortex hemispheres of hypoxia subjects. This
difference may be related to earlier auditory evoked
potential observations which suggested an abnormal
stimulus classification response. Future fMRI studies
can examine auditory physiology changes in human
subjects at risk of chronic hypoxia.
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