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Abstract #3033

Phenotyping assay of neuropathic pain models using selective stimulation for peripheral nerve fibers

Yuji Komaki 1,2 , Keigo Hikishima 1,2 , Shinsuke Shibata 1 , Masaya Nakamura 1 , and Hideyuki Okano 1

1 Keio University, Shinjuku, Tokyo, Japan, 2 Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan

For better understanding of the neuropathic pain, one of the crucial tasks is to develop the evaluation of the pain with high objectivity. The neuropathic pain model with surgical manipulation and with inheritable genetic modification was compared with intact mice using tactile like stimulus for peripheral nerve fibers. The resulting analysis showed, for intact mice, the only S1 was activated. In comparison with intact model, models of neuropathic pain showed the significantly high BOLD activities in ACC and thalamus. Therefore abnormally connection of A lower case Greek beta -fiber was considered as a possible cause of neuropathic pain.

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