Abstract #3041
Functional hippocampal networks changes in relation to spatial learning in hemispherectomized rats
Willem M Otte 1,2 , Pascal Bieleveld 3 , Eric van Diessen 2 , Umesh S Rudrapatna 4 , Kees P Braun 2 , and Rick M Dijkhuizen 1
1
Image Sciences Institute, University Medical
Center Utrecht, Utrecht, Utrecht, Netherlands,
2
Department
of Pediatric Neurology, University Medical Center
Utrecht, Utrecht, Utrecht, Netherlands,
3
Swammerdam
Institute for Life Sciences, University of Amsterdam,
Amsterdam, Netherlands,
4
Diagnostic
Radiology, Yale University School of Medicine, New
Haven, Connecticut, United States
Using resting-state fMRI and minimum-spanning tree
analysis the functional hippocampal network organization
was characterized in relation to the extent of spatial
memory, following experimental hemispherectomy in rats.
The data sheds new light on patterns of change in
functional network organization in the contralateral
hippocampus in relation to changes in spatial memory
after hemispherectomy. Improved spatial memory after
hemispherectomy related to decreased diameter and
increased leaf number of the networks minimum-spanning
tree, indicating a shift towards a more star-like
network. This supports the hypothesis that
reorganization of hippocampal neural networks
contributes to consolidation of spatial learning and
memory after hemispherectomy.
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