Abstract #3043
Two hour-sustained brain activation in the anesthetized rat
Sarah Sonnay 1 , Joo M.N. Duarte 1,2 , Rolf Gruetter 1,3 , and Nathalie Just 1,2
1
LIFMET, EPFL, Lausanne, Switzerland,
2
Radiology,
University of Lausanne, Lausanne, Switzerland,
3
Radiology,
Universities of Geneva and Lausanne, Geneva/Lausanne,
Switzerland
Brain circuitry can be studied with BOLD fMRI, but long
stimulation paradigms might be needed to investigate
long-term neuronal modifications. The aim of the study
was to develop a method to activate the rat brain for 2
hours. SD rats (n=10,32213g) under α-chloralose
anesthesia underwent electrical stimulation of the
forepaw. BOLD fMRI was performed at 9.4T using GE-EPI.
We observed sustained and localized BOLD responses with
minimum activated volume loss during 2 hour-stimulation
in varying the frequency at regular intervals and in
using small ISI. We conclude that the applied paradigm
increases the statistical power for connectivity
analysis.
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