Abstract #3048
Postherpetic neuralgia alters small-world brain functional networks
Yue Zhang 1 , Jing Liu 2 , Longchuan Li 3 , Minyi Du 4 , Wenxue Fang 4 , Dongxin Wang 4 , Xuexiang Jiang 2 , Xiaoping Hu 3 , Jue Zhang 1 , Xiaoying Wang 2 , and Jing Fang 1
1
College of Engineering, Peking University,
Beijing, Beijing, China,
2
Department
of Radiology, Peking University First Hospital, Beijing,
Beijing, China,
3
Biomedical
Imaging Technology Center, Department of Biomedical
Engineering, Georgia Institute of Technology / Emory
University, Atlanta, Georgia, United States,
4
Department
of Anesthesiology, Peking University First Hospital,
Beijing, Beijing, China
Understanding the effect of postherpetic neuralgia (PHN)
pain on brain activity is important for clinic
strategies. This is the first study, to our knowledge,
to relate PHN pain to small-world properties of brain
functional networks. Functional magnetic resonance
imaging was used to construct brain functional networks
during the resting state. Sixteen patients with PHN pain
and sixteen age-matched controls were analyzed (8 males,
8 females for both groups). Decreased local efficiency
for PHN in comparison with the healthy controls was
found. Moreover, regional nodal efficiency was found to
be profoundly affected for PHN.
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