Spatial dynamics separates higher order from primary resting state networks

Investigation and understanding of both intra and inter-subject variability of functional connectivity metrics is critical to be able to use it meaningfully in research and the clinic. Here we report an investigatoin of intra and inter-subject reproducibility of functional networks obtained using spatial ICA. We find that higher-order networks and primary networks have different characteristics of reproducibility and may have implications for their use in studying state, trait or disease.

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