Development and Optimisation of Resting State fcMRI in the Mouse Brain at 9.4T

Resting state functional connectivity MRI (fcMRI) has been applied in humans and rats, in order to gain a deeper understanding of brain function. Despite a degree of reported application of fcMRI in the mouse brain, significant technical challenges remain that are currently holding back the widespread utility of fcMRI to investigate functional changes in genetic mouse models of neurological disease. In this work, we aim to provide an experimental platform for investigating resting state fcMRI in the mouse brain, and show both phantom and in vivo evidence for parameter choices.

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