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Abstract #3057

Use of a neural mass model to investigate the disruption of functional brain networks by simulated focal lesions

Xiaoyun Liang 1 , Alan Connelly 1,2 , and Fernando Calamante 1,2

1 Brain Research Institute, Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia, 2 Department of Medicine, Austin Health and Northern Health, University of Melbourne, Melbourne, VIC, Australia

In this study, a neural mass model has been employed to simulate brain activity at two different levels: neural and BOLD signal. Disrupted network efficiencies have been systematically investigated by simulating each lesioned brain region separately. The relationships between disrupted network efficiencies and degree, betweenness centrality and vulnerability have been studied. Our simulated results indicate that damages to hub regions lead to lower global, but not local efficiency. Overall, our simulated results show that the NMM can predict disrupted network efficiencies and unravel their relationships with network metrics.

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