Abstract #3057
Use of a neural mass model to investigate the disruption of functional brain networks by simulated focal lesions
Xiaoyun Liang 1 , Alan Connelly 1,2 , and Fernando Calamante 1,2
1
Brain Research Institute, Florey Institute
of Neuroscience and Mental Health, Melbourne, VIC,
Australia,
2
Department
of Medicine, Austin Health and Northern Health,
University of Melbourne, Melbourne, VIC, Australia
In this study, a neural mass model has been employed to
simulate brain activity at two different levels: neural
and BOLD signal. Disrupted network efficiencies have
been systematically investigated by simulating each
lesioned brain region separately. The relationships
between disrupted network efficiencies and degree,
betweenness centrality and vulnerability have been
studied. Our simulated results indicate that damages to
hub regions lead to lower global, but not local
efficiency. Overall, our simulated results show that the
NMM can predict disrupted network efficiencies and
unravel their relationships with network metrics.
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