Abstract #3058
Dynamic Resting-state Functional Connectivity in Awake Animals
Zhifeng Liang 1 , Xiao Liu 2 , and Nanyin Zhang 1
1
Department of Biomedical Engineering, The
Pennsylvania State University, University Park, PA,
United States,
2
Laboratory
of Functional and Molecular Imaging, National Institute
of Neurological Disorders and Stroke, Bethesda, MD,
United States
Little is known about the dynamic properties of
resting-state functional connectivity in animals. Here
we studied nonstationary properties of spontaneous BOLD
fluctuations in awake rat brains. Averages of 15%
resting-state fMRI frames based on the BOLD amplitude of
primary somatosensory and infralimbic cortices closely
resembled seed-based functional connectivity patterns.
k-means clustering further revealed distinct time
varying co-activation patterns. Importantly, those CAPs
have consistent temporal evolutions. Therefore, the
current study revealed robust spatial and temporal
patterns of dynamic neural circuitries in awake rat
brains.
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