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Abstract #3058

Dynamic Resting-state Functional Connectivity in Awake Animals

Zhifeng Liang 1 , Xiao Liu 2 , and Nanyin Zhang 1

1 Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, United States, 2 Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States

Little is known about the dynamic properties of resting-state functional connectivity in animals. Here we studied nonstationary properties of spontaneous BOLD fluctuations in awake rat brains. Averages of 15% resting-state fMRI frames based on the BOLD amplitude of primary somatosensory and infralimbic cortices closely resembled seed-based functional connectivity patterns. k-means clustering further revealed distinct time varying co-activation patterns. Importantly, those CAPs have consistent temporal evolutions. Therefore, the current study revealed robust spatial and temporal patterns of dynamic neural circuitries in awake rat brains.

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