Abstract #3075
Altered resting-state functional connectivity of the insular system in chronic cocaine users
Yuzheng Hu 1 , Hong Gu 1 , Betty Jo Salmeron 1 , Xia Liang 1 , Elliot Stein 1 , and Yihong Yang 1
1
Neuroimaging Research Branch, National
Institute on Drug Abuse, NIH, Baltimore, MD, United
States
Accumulative evidence has indicated the involvement of
the insular system in drug addiction by its fundamental
role in interoception. However, relationship between the
interoception, neurobiological measures of insula and
addiction behaviors remains unclear. To address this
question, the current study employed Toronto Alexithymia
Scale and resting-state functional connectivity method
to cocaine dependents and well-matched controls. Altered
insula-cingulate and insula-frontal functional
connectivity, abnormal alexithymic trait and
dis-association between insula-cingulate functional
connectivity and alexithymia were observed in chronic
cocaine users. These findings may shield insight on the
neurobiological bases of drug addiction.
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