The differential progression of functional and structural connectivity in a mouse model of demyelination and remyelination

The increasing use of resting-state fMRI to study brain development and disease progression raises the question of how functional connectivity changes in response to alterations in structural connectivity. Using the cuprizone mouse model of reversible demyelination, we tracked the relationship of S1 functional connectivity to corpus callosum myelination, which was assessed with histology. Results showed different temporal progression of the impairment and the recovery of structural and functional connectivity.

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