New model and confirmatory measurement of the BOLD hemodynamic response function

We present a novel convection-diffusion oxygen transport model to understand the BOLD hemodynamic response function (HRF). A lumped-linear flow model described the CBF response produced by arterial dilation. The CMRO2 response was assumed to have a gamma-function form. The model successfully fit the HRF evoked in human visual cortex and measured using high-resolution fMRI. Results show how CBF and CMRO2 compete with each other to shape the BOLD HRF. The predicted flow and CMRO2 amplitudes agree with previous measurements. Our model provides a detail theoretical framework to understand neurovascular and neurometabolic coupling in the brain.

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