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Abstract #3097

Combining bimodal optogenetic control with BOLD fMRI for causal analysis of the cortico-thalamic circuitry

Florian Schmid 1 , Lydia Wachsmuth 1 , Miriam Schwalm 2 , Albrecht Stroh 2 , and Cornelius Faber 1

1 Department of Clinical Radiology, University of Mnster, Mnster, Germany, 2 Research Group Molecular Imaging and Optogenetics, Johannes Gutenberg-University Mainz, Mainz, Germany

We utilize optogenetic tools for a temporally and spatially defined modulation of components of the cortico-thalamic and the thalamo-cortical neuronal network in nave rats and use BOLD fMRI as a global, noninvasive readout. Our results show positive BOLD activation of S1 sensory cortex upon optogenetic stimulation of S1 or the posterior thalamic nuclei group, and negative BOLD response upon inhibitory stimulation.

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