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Abstract #3098

To Investigate the Hemodynamic Response Function Alterations in Hypercapnia Using Visual Stimulus fMRI

Teng-Chieh Cheng 1 , Yi-Jui Liu 1 , Yi-Hsiung Lee 2 , Kuo-Fang Shao 3 , Chao-Chun Lin 4 , Chia-Wei Lin 4 , and Wu-Chung Shen 4

1 Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, 2 Ph.D. Program of Electrical and Communications Engineering, Feng Chia University, Taichung, Taiwan, 3 Master's Program in Biomedical Informatics and Biomedical Engineering, Feng Chia University, Taichung, Taiwan, 4 Department of Radiology, China Medical University Hospital, Taichung, Taiwan

Neuron activity can be measured by BOLD signal in fMRI study, but BOLD signals could be altered solely by hypercapnia. However, no reports have explored the changes of hemodynamic response function (HRF) in terms of the degrees of hypercapnia. In this study, we investigated the HRF variate from short to long time stimulus within different CO2 concentration inhalation. Our results show the peak of HRF curve is decreased and time-to-peak is ascended with inhaled CO2 fractions. We conclude the restriction of HRF by cerebrovascular reserve is related to CO2 concentration and independent with visual stimulus duration under the steady-state hypercapnia.

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