Abstract #3098
To Investigate the Hemodynamic Response Function Alterations in Hypercapnia Using Visual Stimulus fMRI
Teng-Chieh Cheng 1 , Yi-Jui Liu 1 , Yi-Hsiung Lee 2 , Kuo-Fang Shao 3 , Chao-Chun Lin 4 , Chia-Wei Lin 4 , and Wu-Chung Shen 4
1
Department of Automatic Control Engineering,
Feng Chia University, Taichung, Taiwan,
2
Ph.D.
Program of Electrical and Communications Engineering,
Feng Chia University, Taichung, Taiwan,
3
Master's
Program in Biomedical Informatics and Biomedical
Engineering, Feng Chia University, Taichung, Taiwan,
4
Department
of Radiology, China Medical University Hospital,
Taichung, Taiwan
Neuron activity can be measured by BOLD signal in fMRI
study, but BOLD signals could be altered solely by
hypercapnia. However, no reports have explored the
changes of hemodynamic response function (HRF) in terms
of the degrees of hypercapnia. In this study, we
investigated the HRF variate from short to long time
stimulus within different CO2 concentration inhalation.
Our results show the peak of HRF curve is decreased and
time-to-peak is ascended with inhaled CO2 fractions. We
conclude the restriction of HRF by cerebrovascular
reserve is related to CO2 concentration and independent
with visual stimulus duration under the steady-state
hypercapnia.
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