Abstract #3100
Contributions of excitatory and inhibitory neural activities to BOLD and CBV fMRI
Alexander Poplawsky 1 , Mitsuhiro Fukuda 1 , Xiaopeng Zong 2 , and Seong-Gi Kim 1,3
1
Radiology, University of Pittsburgh,
Pittsburgh, PA, United States,
2
Biomedical
Research Imaging Center, University of North Carolina,
Chapel Hill, NC, United States,
3
Biological
Sciences, Center for Neuroscience Imaging Research,
Institute for Basic Science (IBS), SKKU, Suwon, Korea
We used high-resolution fMRI in the olfactory bulb model
to determine whether inhibitory neurons contribute to
the hemodynamic response. Odor and micro-stimulation of
the anterior commissure (AC) were used to preferentially
evoke excitatory and inhibitory processes, respectively.
For both BOLD and CBV fMRI, we measured hemodynamic
responses in bulb layers corresponding to inhibitory
neuron activity. Of particular interest, the combined
odor plus AC stimulations revealed a relative increase
in fMRI changes at layers corresponding to the net
increase in total synaptic activity (excitatory +
inhibitory). Our data show that excitatory and
inhibitory activities contribute to hemodynamic
responses in the bulb.
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