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Abstract #3101

Repeatibility of M, BOLD, CBF and CMRO 2 for cognitive tasks at 7 Tesla

Steffen N Krieger 1,2 , Claudine J Gauthier 2 , Dimo Ivanov 3 , Laurentius Huber 2 , Elisabeth Roggenhofer 2 , Bernhard Sehm 2 , Robert Turner 2 , and Gary F Egan 1

1 Monash Biomedical Imaging, Monash University, Melbourne, Victoria, Australia, 2 Max-Plank Institute for Human Cognitive and Brain Sciences, Leipzig, Saxonia, Germany, 3 Maastricht University, Netherlands

Calibrated BOLD might be a powerful alternative to classic functional MRI techniques especially as CMRO2 has been found to be more spatially specific when mapping cerebral functional activation compared to BOLD. However, the application of calibrated BOLD at ultra-high field strengths and in combination with more complex cognitive study designs might have been inhibited by the limited knowledge about stability. This study provides evidence that CMRO2 is a reliable biomarker for cognitive studies even when used at ultra-high magnetic fields. The calibrated BOLD technique might be a viable alternative to classic BOLD approaches.

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