Abstract #3103
A breathing apparatus providing improved control of FiO2 and FiCO2 for calibrated fMRI
Felipe B Tancredi 1,2 , Isabelle Lajoie 1,2 , and Richard D Hoge 1,2
1
Institut de gnie biomdical, Universit de
Montral, Montreal, Quebec, Canada,
2
Centre
de recherche de l'IUGM, Montreal, Quebec, Canada
Respiratory manipulations inducing global changes in CBF
and BOLD have been used to measure cerebral vascular
reactivity and metabolism. Respiratory stimulus is
commonly achieved by delivering predetermined
concentrations of gases for inspiration, yielding
end-tidal (ET) values that are used for retrospective
normalization of the fMRI signal. The simplest method
has been to administer O2/CO2 mixtures through low-cost
oxygen masks. However, control over the administered
dose have been difficult using this approach which
hampers reproducibility of ET responses. We have
designed a breathing apparatus allowing precise
adjustments in FiO2/FiCO2 and good intra-subject
reproducibility of ET levels.
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