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Abstract #3104

Full-brain Blood Volume, Oxygenation and Hematocrit Imaging using T1 and T2 Prepared Velocity Selective Labeling

Esben Thade Petersen 1,2 , Jill De Vis 1 , Thomas Alderliesten 3 , C.A.T. van den Berg 2 , and Jeroen Hendrikse 1

1 Department of Radiology, UMC, Utrecht, Netherlands, 2 Department of Radiotherapy, UMC, Utrecht, Netherlands, 3 Department of Neonatology, UMC, Utrecht, Netherlands

In this work we present a method which allows simultaneous full brain measurement of blood-volume, oxygenation and hematocrit. The sequence is based on a T1 and T2 Prepared Velocity Selective Labeling Module. Blood oxygen saturation is an important parameter in neuroscience and for the management of diseases such as stroke or cancer. The sequence was tested using a hypercapnic challenge, which alters the oxygenation levels across the brain. Initial results are promising and further validation work is ongoing in healthy subjects using the reactivity challenge while simultaneously monitoring frontal lobe oxygenation by means of Near InfraRed Spectroscopy.

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