Abstract #3109
Reducing the error: Regional effects of HRF basis functions on EEG-microstate informed fMRI
Simon Schwab 1 , Yosuke Morishima 1 , Thomas Koenig 1 , Thomas Dierks 1 , Andrea Federspiel 1 , and Kay Jann 2
1
University Hospital of Psychiatry,
Department of Psychiatric Neurophysiology / University
of Bern, Bern, Switzerland,
2
Department
of Neurology, University of California, Los Angeles,
California, United States
In the present work, we aimed to compare two sets of
HRFs for microstate-informed resting-state fMRI
analysis: the standard canonical HRF (CA), and the HRFs
extended by the two temporal and dispersion derivatives
(CA+). Fourteen healthy subjects underwent simultaneous
EEG/fMRI. We have found that the extended model CA+
shows lower residuals for visual and right auditory
areas across subjects. These findings provide further
support that the canonical HRF alone may be insufficient
to explain BOLD responses varying across brain regions
and subjects. However, further investigation is needed
to reduce residuals by using more flexible HRF models.
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