Rapid and Accurate T 2 Mapping from Multi Spin Echo Data Using Bloch-Simulation-Based Reconstruction

Accurate quantification of T ₂ values in vivo is a long-standing challenge hampered by the extensive scan times associated with full Spin-Echo ( SE ) acquisitions, or by the inherent bias of rapid multi-SE sequences resulting from stimulated and indirect echoes. Recently, a novel proof-of-principle T ₂ mapping technique the echo-modulation curve ( EMC ) algorithm has been proposed based on precise Bloch simulations. In this work we establish the EMC technique applicability to various body regions, analyze its accuracy and precision at different SNR levels and present extensions both to non-Cartesian trajectories and to multiparametric mapping of T ₂ relaxation, proton density and transmit B ₁ ⁺ profile.

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