Abstract #3132
ASSESSMENT OF IRON OVERLOAD IN THE LIVER WITH MRI T2*. THE EFFECTS OF THE ANALYSIS TECHNIQUE ON T2* ESTIMATION
El-Sayed H. Ibrahim 1 , Ayman M. Khalifa 2 , Ahmed K. Eldaly 2 , and Andrew W. Bowman 1
1
Mayo Clinic, Jacksonville, Florida, United
States,
2
Helwan
University, Cairo, Egypt
MRI has been established as an effective technique for
evaluating iron overload by measuring T2* in the liver.
Although the process of calculating T2* is conceptually
straightforward, various factors associated with image
analysis could change the resulting measurement,
including the signal averaging method, exponential
fitting model, region-of-interest (ROI) location and
size, echo truncation, iron overload severity, and
inter-/intra-observer variabilities. In this study, we
evaluate the influences of these factors on T2*
estimation in calibrated phantoms and eleven patients
with different degrees of iron overload. The results
show various degrees of similarities and differences
between the performances of different analysis
approaches.
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