Abstract #3134
MRI evaluation of the relationship between R 2 , R 2 *, and tissue iron in the human basal ganglia
Joanna Collingwood 1,2 , Mary Finnegan 1 , Zobair Arya 3 , Jean-Pierre Hagen 1 , Saherabanu Chen 1 , Alimul Chowdhury 4 , Sarah Wayte 5 , Eddie Ngandwe 5 , Naomi Visanji 6 , Jon Dobson 7 , Penny Gowland 8 , Lili-Naz Hazrati 9 , and Charles Hutchinson 5,10
1
School of Engineering, University of
Warwick, Coventry, West Midlands, United Kingdom,
2
Materials
Science and Engineering, University of Florida,
Gainesville, Florida, United States,
3
Department
of Physics, University of Warwick, West Midlands, United
Kingdom,
4
School
of Psychology, University of Birmingham, West Midlands,
United Kingdom,
5
University
Hospitals Coventry and Warwickshire, West Midlands,
United Kingdom,
6
Morton
and Gloria Shulman Movement Disorders Centre, Toronto
Western Hospital, Ontario, Canada,
7
J.
Crayton Pruitt Family Department of Biomedical
Engineering, University of Florida, Florida, United
States,
8
School
of Physics & Astronomy, University of Nottingham,
Nottinghamshire, United Kingdom,
9
Tanz
Centre for Research in Neurodegenerative Disease,
University of Toronto, Ontario, Canada,
10
Warwick
Medical School, University of Warwick, West Midlands,
United Kingdom
R2 and R2* were determined for primary regions in the
basal ganglia. Ten adult volunteers were measured at
3.0T and 1.5T on clinical platforms; R2*, R2, and the
field-dependent R2 increase (FDRI) were compared with
previously reported iron concentrations for the same
regions. A set of post-mortem tissues were measured at
9.4T using a Bruker MicWB40; relationships between iron,
R2, and R2* were directly evaluated by mapping tissue
iron distribution with synchrotron X-ray fluorescence,
enabling spatial correlation with MRI maps. These data
indicate that at 9.4T the linear relationship between
both R2 and R2*, and tissue iron concentration, is
preserved.
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