DUAL-ENERGY COMPUTED TOMOGRAPHY (DECT) FOR CHARACETRIZING TISSUE IRON OVERLOAD. COMPARISON TO MRI T2*

T2*-weighted MRI has been established for evaluating myocardial iron overload with strong correlation with biopsy. The recently introduced dual-energy computed-tomography (DECT) has the potential for evaluating iron overload without energy-dependent CT attenuation or tissue fat effects. This study investigates the performance of DECT for evaluating myocardial iron overload (from images acquired at different diagnostic imaging energies of 80/100/120/140 kVp) and compare the results to MRI T2* based on experiments on phantoms with calibrated iron concentrations. DECT showed high accuracy for evaluating iron overload independent of the implemented imaging energy, with the results comparable to those from MRI T2* measurements.

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