Meeting Banner
Abstract #3147

A novel approach for fast MWF quantification

Sofya Kulikova 1 , Lucie Hertz-Pannier 1 , Ghislaine Deahene-Lambertz 2 , Cyril Poupon 3 , and Jessica Dubois 2

1 UMR 663 Neurospin/UNIACT, INSERM-CEA, Gif-sur-Yvette, France, 2 UMR 992 Neurospin/UNICOG, INSERM-CEA, Gif-sur-Yvette, France, 3 Neurospin/UNIRS, CEA-Saclay, Gif-sur-Yvette, France

Myelin Water Fraction (MWF) is computed from multicomponent relaxation analysis that requires long acquisition and post-processing times limiting its practical application in infants. Here we suggest a novel 2-step strategy for fast MWF quantification. We fitted a 3-component model (myelin-related water, intra/extra-cellular water, CSF) with adults data having a large number of measurements to identify the most appropriate T1 and T2 values for each component over the whole brain. These values were fixed for the following MWF quantification with a reduced number of measurements. Infant MWF maps showed progressive myelination with age and were in qualitative agreement with other studies.

This abstract and the presentation materials are available to members only; a login is required.

Join Here