Abstract #3147
A novel approach for fast MWF quantification
Sofya Kulikova 1 , Lucie Hertz-Pannier 1 , Ghislaine Deahene-Lambertz 2 , Cyril Poupon 3 , and Jessica Dubois 2
1
UMR 663 Neurospin/UNIACT, INSERM-CEA,
Gif-sur-Yvette, France,
2
UMR
992 Neurospin/UNICOG, INSERM-CEA, Gif-sur-Yvette,
France,
3
Neurospin/UNIRS,
CEA-Saclay, Gif-sur-Yvette, France
Myelin Water Fraction (MWF) is computed from
multicomponent relaxation analysis that requires long
acquisition and post-processing times limiting its
practical application in infants. Here we suggest a
novel 2-step strategy for fast MWF quantification. We
fitted a 3-component model (myelin-related water,
intra/extra-cellular water, CSF) with adults data
having a large number of measurements to identify the
most appropriate T1 and T2 values for each component
over the whole brain. These values were fixed for the
following MWF quantification with a reduced number of
measurements. Infant MWF maps showed progressive
myelination with age and were in qualitative agreement
with other studies.
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