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Abstract #3148

Limitations in Biexponential Fitting of Nuclear Magnetic Resonance (NMR) Inversion-Recovery Data to Differentiate Between Cell Compartmental NMR Signals

Mohammed Salman Shazeeb 1,2

1 Radiology, University of Massachusetts Medical School, Worcester, MA, United States, 2 Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, United States

A biexponential model can be used to fit inversion-recovery NMR data to differentiate between compartmental relaxation times and magnetization fractions in order to measure compartment-specific apparent diffusion coefficients. Due to the presence of noise in acquired data and sensitivity to actual observed parameter values, the fitted parameters display different amounts of error depending on whether an extracellular or intracellular contrast agent is administered. In this study, simulations of data sets corresponding to both scenarios were generated to determine the effects of signal to noise and parameter limitations on the constraints of fitting by calculating the root mean square percentage error.

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