Abstract #3148
Limitations in Biexponential Fitting of Nuclear Magnetic Resonance (NMR) Inversion-Recovery Data to Differentiate Between Cell Compartmental NMR Signals
Mohammed Salman Shazeeb 1,2
1
Radiology, University of Massachusetts
Medical School, Worcester, MA, United States,
2
Biomedical
Engineering, Worcester Polytechnic Institute, Worcester,
MA, United States
A biexponential model can be used to fit
inversion-recovery NMR data to differentiate between
compartmental relaxation times and magnetization
fractions in order to measure compartment-specific
apparent diffusion coefficients. Due to the presence of
noise in acquired data and sensitivity to actual
observed parameter values, the fitted parameters display
different amounts of error depending on whether an
extracellular or intracellular contrast agent is
administered. In this study, simulations of data sets
corresponding to both scenarios were generated to
determine the effects of signal to noise and parameter
limitations on the constraints of fitting by calculating
the root mean square percentage error.
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