Abstract #3149
The exchange pathways of NOE-CEST as revealed by NMR study
Haifeng Zeng 1,2 , Nirbhay N. Yadav 1,2 , Xiang Xu 1,2 , Kannie W.Y. Chan 1,2 , Guanshu Liu 1,2 , Michael T. McMahon 1,2 , Peter C.M. van Zijl 1,2 , and Jiadi Xu 1,2
1
Kirby Center, Kennedy Krieger Institute,
Baltimore, MD, United States,
2
Department
of Radiology, Johns Hopkins University School of
Medicine, Baltimore, MD, United States
Amide Proton Transfer (APT) and relayed NOE CEST (rNOE-CEST)
images of endogenous mobile protein in vivo can be used
to detect pH changes as well as tumors. However, the
precise mechanisms underlying the magnetization transfer
contributions among water, amide protons and aliphatic
protons in mobile proteins is still under debate. Using
a series of NMR experiments on egg white, we confirmed
that the magnetization transfer from water to aliphatic
protons is relayed through amide protons.
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