3D Fast Spin-Echo Amide Proton Transfer MR with Intrinsic Field Homogeneity Correction for Neuro-Oncology Applications
Jochen Keupp 1 , Mariya Doneva 1 , Julien Sngas 1 , Silke Hey 2 , and Holger Eggers 1
Philips Research Europe, Hamburg, Germany,
Healthcare, Best, Netherlands
Amide proton transfer (APT), an endogenous saturation
transfer contrast, has recently gained attention as a
molecular imaging approach in oncology and neurology.
For clinical applications, 3D coverage of the whole
tumor or whole brain within acceptable acquisition time
as well as a robust field homogeneity correction is
essential. In this work, we combined previous approaches
for fast-spin echo APT MRI with radial phase encoding
and intrinsic 3-point spin-echo Dixon B
and homogeneity correction. The volunteer study (N=9)
demonstrates the ability to obtain homogeneous and high
SNR 3D APT images in the brain using a single
examination in less than 5 minutes.
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