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Abstract #3150

3D Fast Spin-Echo Amide Proton Transfer MR with Intrinsic Field Homogeneity Correction for Neuro-Oncology Applications

Jochen Keupp 1 , Mariya Doneva 1 , Julien Sngas 1 , Silke Hey 2 , and Holger Eggers 1

1 Philips Research Europe, Hamburg, Germany, 2 Philips Healthcare, Best, Netherlands

Amide proton transfer (APT), an endogenous saturation transfer contrast, has recently gained attention as a molecular imaging approach in oncology and neurology. For clinical applications, 3D coverage of the whole tumor or whole brain within acceptable acquisition time as well as a robust field homogeneity correction is essential. In this work, we combined previous approaches for fast-spin echo APT MRI with radial phase encoding and intrinsic 3-point spin-echo Dixon B 0 mapping and homogeneity correction. The volunteer study (N=9) demonstrates the ability to obtain homogeneous and high SNR 3D APT images in the brain using a single examination in less than 5 minutes.

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