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Abstract #3154

NOE-CEST and amineproton exchange imaging of mouse brain with suppression of MTC effects

Jiadi xu 1,2 , Kannie W. Y. Chan 1,2 , Xiang Xu 1,2 , Nirbhay Yadav 1,2 , Guanshu Liu 1,2 , Michael T. McMahon 1,2 , and Peter C. M. van Zijl 1,2

1 Radiology Department, Johns Hopkins University, Baltimore, MD, United States, 2 Kennedy Krieger Institute, Baltimore, MD, United States

A new CEST scheme was developed using the variable delay multi-pulse train CEST (VDMP-CEST) in which the semi-solid magnetization transfer contrast (MTC) contribution was removed based on its exchange rate. The scheme requires acquisition of two images: one at zero inter-pulse delay and a second with an inter-pulse delay at which the MTC signal is comparable to that at zero delay. Consequently, subtracting the two images removes MTC. In addition, direct saturation is reduced, while CEST contrast in different exchange rate regimes remains preserved. The new method is demonstrated on phantoms and on normal mouse brain.

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