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Abstract #3155

Hybrid frequency encoding/water relaxation method for detecting exchangeable solute protons with increased sensitivity and specificity

Nirbhay N Yadav 1,2 , Jiadi Xu 1,2 , Xiang Xu 1,2 , Michael T McMahon 1,2 , and Peter C M van Zijl 1,2

1 Radiology, The Johns Hopkins University, Baltimore, MD, United States, 2 FM Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States

Measurement of chemical exchange is important for characterizing many biological processes. Current methods for detecting exchange in spectroscopy are classified based on whether exchange is slow, intermediate, or fast on the NMR time scale. Here we demonstrate a pulse sequence with solute proton frequency encoding and water detection that has the ability to distinguish exchange contributions over a large range of exchange rates (slow-intermediate-fast). When exchange is slow-intermediate, solute protons are labeled and detected with enhanced sensitivity. At higher exchange rates, changes in the water line shape are detected. This principle is demonstrated for the metabolites creatine, myo-inositol, and glutamate.

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