Abstract #3156
UCEPR: Ultrafast Localized CEST Spectroscopy with PRESS
Zheng Liu 1,2 , Ivan E. Dimitrov 2,3 , Robert E. Lenkinski 1,2 , and Elena Vinogradov 1,2
1
Radiology, University of Texas Southwestern
Medical Center, Dallas, Texas, United States,
2
Advanced
Imaging Research Center, University of Texas
Southwestern Medical Center, Dallas, Texas, United
States,
3
Philips
Medical Systems, Highland Heights, Ohio, United States
Chemical Exchange Saturation Transfer often utilizes
acquisition of multi-point Z-spectra, which can be time
consuming. Recently an ultrafast Z-spectroscopy method
was introduced, employing frequency-encoding gradient
during saturation and readout-gradient, thus collecting
the whole data with two scans. Here we combine the
method with PRESS to achieve localized ultrafast
Z-spectroscopy (UCEPR). The sequence is straightforward
to implement on clinical scanner and provides CEST
effects comparable to the standard Z-spectra UCERP
provides localized CEST information on a time scale
currently unattainable and we anticipate that it will
complement conventional imaging and spectroscopy methods
in-vivo.
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