Abstract #3157
Using CEST to Detect Glycogen-depleting Exercise-Induced Changes In Vivo
Ying Cheng 1,2 , Kilian Weiss 3 , Peter van Zijl 1,4 , Kathleen Zackowski 5,6 , and Craig Jones 1,4
1
Neurosection, Div. of MRI Research, Dept. of
Radiology, Johns Hopkins University School of Medicine,
Baltimore, MD, United States,
2
Dept.
of Biomedical Engineering, Johns Hopkins University
School of Medicine, Baltimore, MD, United States,
3
Dept.
of Cardiology, Johns Hopkins University School of
Medicine, Baltimore, MD, United States,
4
F. M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, MD, United States,
5
Motion
Analysis, Kennedy Krieger Institute, Baltimore, MD,
United States,
6
Dept.
of Physical Medicine & Rehab, Neurology, Johns Hopkins
University School of Medicine, Baltimore, MD, United
States
Magnetic resonance spectroscopy (MRS) techniques have
been applied to study skeletal muscle energetics.
However they suffer from poor spatial resolution and low
sensitivity. Chemical exchange saturation transfer
(CEST) is a new MRI method that can indirectly detect
endogenous cellular substances (e.g. creatine, glycogen)
and proteins and metabolites through their exchangeable
protons. Here, we applied the CEST technique in human
calf muscle at 3T to a previously described exercise
regime reported to be glycogen depleting only without a
change in phosphocreatine. We demonstrate the potential
of detecting exercise-induced changes in CEST signal,
which could include glycogen, creatine, and/or T2
changes.
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