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Abstract #3159

Simultaneously Measuring Glycogen and Lipid Levels Using Localized CEST Spectroscopy at 3T

Stephen J Bawden 1 , Olivier Mougin 1 , Karl Hunter 2 , Luca Marciani 3 , and Penny Gowland 1

1 SPMMRC, University of Nottingham, Nottingham, United Kingdom, 2 Unilever Discover, Bedford, United Kingdom, 3 NDDC Biomedical Research Unit, University of Nottingham, Nottingham, United Kingdom

Glycogen and Lipid levels are measured simultaneously using localised GlycoCEST proton MRS. Phantoms with glycogen, glucose and coconut milk were scanned using frequency stepped pre-saturation pulses and PRESS localization for MRS acquisition. Individual spectra were averaged in saturated and non-saturated regions to determine lipid-to-water peak ratios, and the asymmetry of off-resonance saturation water peak heights used to determine the CEST effect. This sequence was tested in vivo in the liver for varying off resonance saturations, and for varying pulse powers. This pilot study offers a promising new technique for reducing study time and costs whilst simultaneously measuring multiple metabolic pathways.

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