Abstract #3160
Monitoring extracelluar pH, spatial heterogeneity and contrast agent uptake in lymphoma tumor growth with acidoCEST MRI
Liu Qi Chen 1 , Christine M. Howison 2 , Amanda F. Baker 3 , and Mark D. Pagel 2
1
Chemistry & Biochemistry, University of
Arizona, Tucson, AZ, United States,
2
Biomedical
Engineering, University of Arizona, Tucson, AZ, United
States,
3
The
University of Arizona Cancer Center, University of
Arizona, Tucson, AZ, United States
Extracelluar pH (pHe) is a hallmark for tumor
microenvironment. A non-invasive MRI method, term
acidoCEST MRI, was used to accurately measure pHe and
assess tumor acidosis. The pixel-wise pHe mapping allows
us to access spatial heterogeneity and also contrast
agent uptake. We have applied acidoCEST MRI to monitor
effects of tumor growth in lymphoma tumor model, Raji,
Ramos and Granta519. Our results showed mildly acidic
pHe in all 3 tumor models. Granta519 pHe decreased over
the course of 3 weeks. The % contrast agent uptake
evaluated using acidoCEST MRI correlated with ex vivo
VEGF-A score.
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