Bicarbonate as a theragnostic CEST agent for glioma models
Francisco Torrealdea 1 , Marilena Rega 1 , Joanne Lau 1 , Jessica Broni 1 , Sebastian Brandner 1 , Simon Walker-Samuel 2 , David L Thomas 1 , and Xavier Golay 1
Institute of Neurology, UCL, London, London,
for Advance Biomedical Imaging, UCL, London, London,
Upregulated aerobic glycolysis in tumours causes acidic
extracellular pH. Changes in pH can be detected in-vivo
by CEST MRI. The goal of this study is to assess the
CEST signal response of brain gliomas following the
administration of an intra-peritoneal (IP) bolus of
sodium bicarbonate. This preliminary study shows the
potential of bicarbonate as a theragnostic CEST agent
for the treatment and early assessment of gliomas.
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