Abstract #3161
Bicarbonate as a theragnostic CEST agent for glioma models
Francisco Torrealdea 1 , Marilena Rega 1 , Joanne Lau 1 , Jessica Broni 1 , Sebastian Brandner 1 , Simon Walker-Samuel 2 , David L Thomas 1 , and Xavier Golay 1
1
Institute of Neurology, UCL, London, London,
United Kingdom,
2
Centre
for Advance Biomedical Imaging, UCL, London, London,
United Kingdom
Upregulated aerobic glycolysis in tumours causes acidic
extracellular pH. Changes in pH can be detected in-vivo
by CEST MRI. The goal of this study is to assess the
CEST signal response of brain gliomas following the
administration of an intra-peritoneal (IP) bolus of
sodium bicarbonate. This preliminary study shows the
potential of bicarbonate as a theragnostic CEST agent
for the treatment and early assessment of gliomas.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
