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Abstract #3162

Generating Quantitative pH Maps in Hyper-acute Stroke Patients Using Amide Proton Transfer (APT) Imaging

Yee Kai Tee 1 , George Harston 2 , Nicholas Blockley 3 , Thomas Okell 3 , Jacob Levman 1 , Martino Cellerini 4 , Fintan Sheerin 4 , Peter Jezzard 3 , James Kennedy 2 , Stephen Payne 1 , and Michael Chappell 1

1 Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, Oxfordshire, United Kingdom, 2 Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxfordshire, United Kingdom, 3 FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxfordshire, United Kingdom, 4 Department of Neuroradiology, Oxford University Hospitals NHS Trust, Oxfordshire, United Kingdom

Amide proton transfer (APT) imaging is a variant of chemical exchange saturation transfer (CEST) that has potential for assessing ischemic tissue at risk for infarction. In this study, APT data in healthy subjects and hyper-acute stroke patients within 6 hours of onset were acquired. A quantitative model-based analysis, where the modified Bloch equations were fitted to measured data using Bayesian algorithm, was used to quantify the APT effect. Based on the quantified APT effect and a previously published pH versus amide proton exchange rate relationship, quantitative pH maps in healthy subjects and stroke patients were generated.

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