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Abstract #3169

Accelerated In Vivo 3D Chemical Exchange Saturation Transfer (CEST) Imaging using dynamic Compressed Sensing

Juyoung Lee 1 , Paul Kyu Han 1 , Seung-Hong Choi 2 , Sung-Hong Park 1 , and Jong Chul Ye 1

1 Department of Bio and Brain Engineering, KAIST, Daejeon, Yuseong-gu, Korea, 2 Department of Radiology, Seoul National University Hospital, Seoul, Korea

CEST can be combined with 3D gradient echo imaging to minimize distortion and avoid slice-dependent saturation frequency variations, but the spatial coverage may be limited. One potential approach to overcome this limitation is to use compressed sensing (CS). In this study, we successfully obtained in vivo 3D CEST images using k-t FOCUSS at 3T. Experimental results show that CS acceleration by a factor of 4 works well for both 3D CEST-bSSFP and 3D CEST-FISP and improves the z-spectrum compared to parallel imaging method, which confirms that combination of CS may be a good solution for 3D- CEST imaging.

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