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Abstract #3194

Simultaneous Determination of Electrical Properties and Proton Density in a Generalized Gradient-based Electrical Properties Tomography

Jiaen Liu 1 , Xiaotong Zhang 1 , Pierre-Francois Van de Moortele 2 , Sebastian Schmitter 2 , and Bin He 1,3

1 Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, United States, 2 Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, United States, 3 Institute for Engineering in Medicine, University of Minnesota, Minneapolis, Minnesota, United States

Electrical properties tomography (EPT), which utilizes measurable radiofrequency field (B1) information to image the electrical properties (EP) of tissue, including conductivity and permittivity, holds promises in both clinical diagnosis and real time subject-specific quantification of specific absorption rate. In a previous study, we have derived and validated a gradient-based EPT (gEPT) approach with significantly improved boundary reconstruction and fidelity against measurement noise. Here, a more generalized method for gEPT is introduced to quantitatively solve gEPT under the practical situation when proton density is unknown. As a result, both EP and proton density can be obtained with satisfactory boundary reconstruction.

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