Abstract #3199
Refocusing Flip Angle Map Constrained Fitting for Indirect Echo Compensated T2 Mapping
Chuan Huang 1 , Maria I Altbach 2 , Quanzheng Li 1 , Xiaomeng Zhang 1 , and Georges El Fakhri 1
1
Center for Advanced Medical Imaging
Sciences, Massachusetts General Hospital, Harvard
Medical School, Boston, MA, United States,
2
Medical
Imaging, The University of Arizona, Tucson, AZ, United
States
multiple spin-echo is generally used due for T2 mapping
to the long acquisition time required by single
spin-echo strategies. However, because of pulse
imperfection, the signal acquired by MSE sequence is
generally contaminated by indirect echoes. Several
groups have investigated T2 fitting techniques
incorporating the indirect echoes into the signal model.
One common aspect of these model-based indirect echo
compensated T2 estimation techniques is that the flip
angles of the refocusing pulses are also being fitted to
the acquired TE images for each pixel along with T2
values. However, due to the non-convex nature of the
cost function in the fitting, there is an ambiguity
issue for the refocusing flip angles. Breikreutz et al
proposed to use separately acquired rFA map to improve
the accuracy. However, the additional acquisition time
for rFA mapping is not desirable, and the approach also
suffers from subject motion between these two
acquisitions. In this work, we propose an iterative
refocusing flip angle map constrained T2 decay model
fitting technique with indirect echo compensated to
solve the ambiguity problem without additional
acquisition.
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