Abstract #3200
Optimizing single component DESPOT using a Cramer-Rao Lower Bound framework
Rui Pedro A. G. Teixeira 1,2 , Shaihan J. Malik 1,3 , and Joseph V. Hajnal 1,3
1
Division of Imaging Sciences and Biomedical
Engineering, King's College London, London, London,
United Kingdom,
2
Institute
of Biophysics and Biomedical Engineering, Faculty of
Sciences, Lisbon, Lisbon, Portugal,
3
Centre
for the Developing Brain, King's College London, London,
London, United Kingdom
The Driven Equilibrium Single Pulse Observation of T1 &
T2 (DESPOT) relaxometry technique aims to provide high
quality 3D maps of T1 and T2 within a clinical time
frame. We propose an optimization method built on the
Cramr-Rao Lower Bound to guarantee low estimation
standard deviation over a defined range of relaxation
times and use it to design optimal single compartment
DESPOT acquisitions for adult and neonatal brain.
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