Efficient Imaging Parameters for Quantitative 3D T1rho Mapping of the Brain

Quantitative T1ρ mapping has tremendous potential to probe a variety of brain diseases. However, T1ρ mapping has largely been limited to 2D single-slice acquisitions. 3D mapping would be a major advance to provide high spatial resolution maps of the entire brain, but acquisition time is a significant challenge. Here we simulate tradeoffs of imaging parameters for recently-described rapid segmented 3D T1ρ mapping sequences to determine which sets of parameters provide the shortest acquisition times to achieve target T1ρ precision thresholds. This is a critical step toward fulfilling the need to efficiently acquire 3D T1ρ maps of the brain.

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