Abstract #3203
Imaging T 1 , T 2 and proton density with minimum possible acquisitions
Guan Wang 1,2 , Abdel-Monem M. El-Sharkawy 2 , and Paul A. Bottomley 1,2
1
Electrical & Computer Engineering, Johns
Hopkins University, Baltimore, MD, United States,
2
Russell
H. Morgan Dept. of Radiology & Radiological Sciences,
Johns Hopkins University, Baltimore, MD, United States
T
1
, T
2
and
proton density contain almost all of the information
that MRI routinely uses in clinical diagnosis and
research, but are seldom imaged directly. Moreover,
measurements depend critically on B
1
-field
homogeneity making field mapping essential at higher
field strengths. Here, a novel method that measures T
1
,
T
2
, PD and B
1
with
only four acquisitionsthe minimum possibleis
presented. This Tri-FA method encodes T
1
with
three varied flip-angles, and T
2
via
long 0 BIR-4 pre-pulses instead of spin-echoes. 2D and
3D Tri-FA imaging is demonstrated in vitro and in
human brain studies at 3 Tesla.
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