Combined Effects of Albumin and Manganese on 1H Relaxation Rates of aCSF

The use of manganese (Mn) as a contrast agent for neuro-anatomical and functional mapping has been studied in animal models for the last decade. Mn contrast enhancement is directly proportional to the changes in relaxation rates in brain tissue. However, the binding of Mn to proteins may alter its relaxation. Thus protein levels and metabolic processes that produce them in the brain and cerebrospinal fluid (CSF) will alter Mn contrast. The aim of this study was to investigate the relaxation rate of Mn in artificial CSF (aCSF), when different levels of protein are present. We found that the concentration of protein used affected both the T1 and T2 relaxation times.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.