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Abstract #3227

Voxel-based quantitative MRI in multiple sclerosis

Maria Engstrm 1,2 , Jan B M Warntjes 2,3 , Anders Tisell 2,4 , Anne-Marie Landtblom 2,5 , and Peter Lundberg 2,4

1 Radiology, Linkping University, Linkping, Sweden, 2 Center for Medical Image Science and Visualization (CMIV), Linkping University, Linkping, Sweden, 3 Clinical Physiology, Linkping University, Linkping, Sweden, 4 Radiation Physics, Linkping University, Linkping, Sweden, 5 Neurology, Linkping University, Linkping, Sweden

The purpose was to improve objective measures for brain tissue characterization and visualization in groups using quantitative MRI in combination with brain normalization. Nineteen multiple sclerosis (MS) patients and 20 healthy controls were investigated with quantitative MRI, measuring the relaxation rates, R1 and R2, and the proton density. Voxel-based statistical analysis showed shared tissue aberrations in the MS patients and aberrations that were related to MS disability. Quantitative MRI together with voxel-based statistical analysis and multi-parametric visualization is an up-and-coming method to study neuropathology and its neuroanatomical correlation to clinical disability measures that are common for an entire group.

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